Method Development, Method Validation, Simultaneous Estimation of Paracetamol and Ibuprofen Solid Dosage Form by RP-HPLC Method

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Method development demonstrated accuracy and specificity for paracetamol and ibuprofen estimation, indicating potential for combined dosage forms.

The RP-HPLC method accurately estimates paracetamol and ibuprofen simultaneously in tablet formulations.
Validation metrics such as specificity and robustness were confirmed during method development for the RP-HPLC.
The method utilizes a C18 column with an isocratic mobile phase of phosphate buffer and acetonitrile at a flow rate of 0.7 ml/min.
This method addresses a gap, as previous reports did not validate the simultaneous estimation of these drugs in combined forms.

Sai et al. (2025) studied this question.

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Method development demonstrated accuracy and specificity for paracetamol and ibuprofen estimation, indicating potential for combined dosage forms.