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September 19, 2025Russian Journal of ImmunologyOpen Access

Assessment of IL-6 and IL-8 levels in community-acquired pneumonia in children

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Authors

NAN.A. AnikeevaAZA.Yu. ZhulevaNBN.А. Belykh

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Overview

Assessment reveals elevated IL-6 and IL-8 levels in severe cases of community-acquired pneumonia, suggesting their role as biomarkers.

Key Points

  • Children with severe pneumonia showed significantly higher levels of IL-6 (2.2 times) and IL-8 (3.6 times) than those with mild pneumonia.
  • Positive correlations were established between IL-6 levels and disease severity (r = 0.68, p < 0.0001) and IL-8 with leukocytosis (r = 0.35, p < 0.05).
  • An enzyme immunoassay was used to measure IL-6 and IL-8 concentrations in blood serum from 37 children diagnosed with community-acquired pneumonia.
  • The findings indicate that increased serum levels of IL-6 and IL-8 may serve as promising biomarkers for assessing pneumonia severity.

Cite This Study

Anikeeva et al. (2025) studied this question.

synapsesocial.com/papers/68d436fd713b0b5dfea76915https://doi.org/10.46235/1028-7221-17196-aoi
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Also Consider

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  1. 1Evaluation Of IL-8 As A Diagnostic Marker In The Diagnosis Of Bacterial Pneumonia2025
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  3. 3Diagnostic value of systemic inflammation markers in differentiating complicated and simple parapneumonic effusions in children2025
  4. 4THE ASSOCIATION OF INTERLEUKIN-6 AND PROCALCITONIN LEVELS WITH CLINICAL OUTCOME OF COVID-19 DISEASE2025
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