Observational analysis found elevated endothelial dysfunction in children with SARS-CoV-2 pneumonia, suggesting a link to inflammation and disease severity.
Key Points
Endothelial dysfunction is evident in children with SARS-CoV-2 pneumonia, linked to inflammation and disease severity.
Levels of endothelin-1 and vascular endothelial growth factor were significantly higher in severe pneumonia cases by about 30%.
Analysis of 160 children with SARS-CoV-2 pneumonia showed relationships with C-reactive protein and other inflammatory markers.
This highlights the importance of monitoring endothelial dysfunction in pediatric patients with COVID-19 pneumonia.