September 19, 2025Open Access

Aging diminishes interlaminar functional connectivity in the mouse cortical V1 and CA1 hippocampal regions

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Discussion

Chronic recording reveals aging reduces functional connectivity in cortical and hippocampal regions, suggesting implications for cognitive health.

Aging impairments in network-level synchrony were noted across multiple frequency bands.
Global reductions in local field potential power were observed in aged mice compared to young mice.
Longitudinal measures of electrophysiological activity indicate minimal loss of single-neuron function in aged mice.
These findings emphasize the importance of chronic, multi-region studies to understand brain aging mechanisms.

Thai et al. (2025) studied this question.

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Chronic recording reveals aging reduces functional connectivity in cortical and hippocampal regions, suggesting implications for cognitive health.