Mapping structure and perfusion alterations in the hippocampus subfields and connected cortex across the adult lifespan

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Hippocampal subfields showed significant age-related structural changes, affecting cognition with aging.
Analysis of 540 subjects revealed a correlation between arterial transit time and atrophy, particularly in females.
Findings highlight the relationship between structural integrity and vascular function in the aging hippocampus.
Mapping trajectories of change in hippocampal subfields can inform age-related cognitive decline and gender differences.

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Analysis reveals structural and vascular changes in hippocampal subfields and cortex during aging, suggesting impacts on cognition.

Wen et al. (2025) studied this question.

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