September 10, 2025Open Access

Preserved synaptic architecture but impaired ketamine-induced synaptic plasticity of layer 5 pyramidal neurons in the aged frontal cortex

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Aged mice exhibit impaired cognitive flexibility during tasks, indicating deficits in executive function and adaptability.
Significant differences in spine density and stability were observed between female and male aged mice.
Baseline dendritic spine architecture is maintained in aged mice, despite impaired responses to ketamine treatment.
Age-related impairments in synaptic plasticity highlight critical therapeutic targets for restoring cognitive function.

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Observational analysis demonstrates impaired synaptic plasticity in aged pyramidal neurons, suggesting age impacts cognitive flexibility.

Ugidos et al. (2025) studied this question.

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