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September 18, 2025Open Access

Cardio-Kidney-Metabolic Syndrome: Candidate Subtypes and Genetic Risk Factors

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Authors

HDHylke C. DonkerVBVandana BishtODOm Prakash Dwivedi

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Overview

Analysis uncovers five candidate CKM subtypes and 57 genetic variants linked to health outcomes and diseases.

Key Points

  • Five distinct candidate CKM subtypes were identified, each linked to specific health biomarkers and diseases.
  • The genetic analysis revealed 57 significant variants, most of which were subtype-specific, enhancing understanding of CKM syndrome.
  • Combining biomarkers improved the detection of genetic variants related to distinct health outcomes in CKM syndrome.
  • The study emphasizes the importance of genetic underpinnings and health outcomes in addressing the heterogeneity of CKM syndrome.

Cite This Study

Donker et al. (2025) studied this question.

synapsesocial.com/papers/68d434ef713b0b5dfea74cd2https://doi.org/10.21203/rs.3.rs-7602643/v1
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  1. 1Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Disease Risk2025
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  4. 4Genomic structural equation modelling provides insights into the shared multivariate genetic architecture of cardio-kidney-metabolic syndrome components2025 · 1 citations
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