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July 16, 2025

Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Syndrome Risk

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Authors

MZMeng ZhouWSWenxiu SunYGYuhan Gao

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Overview

Cross-sectional study identifies distinct metabolic subtypes in individuals with cardiovascular-kidney-metabolic syndrome, suggesting early biomarker potential.

Key Points

  • Distinct metabolic subtypes associated with cardiovascular-kidney-metabolic syndrome were identified using metabolomic profiling.
  • A total of 390 metabolites were analyzed, leading to the discovery of three metabolic clusters with varying metabolic statuses.
  • High-risk individuals were predominantly classified into the cluster showing elevated metabolic status, indicating a strong correlation with CKM risk.
  • A panel of 20 metabolites demonstrated high diagnostic performance for stage 3 CKM, enhancing early detection efforts.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccd16https://doi.org/10.21203/rs.3.rs-7120089/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic Profiling Reveals Interindividual Metabolic Variability and Its Association with Cardiovascular-Kidney-Metabolic Disease Risk2025
  2. 2Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk2025 · 12 citations
  3. 3Cardio-Kidney-Metabolic Syndrome: Candidate Subtypes and Genetic Risk Factors2025
  4. 4Association between cardiovascular–kidney–metabolic health metrics and long-term cardiovascular risk: Findings from the Chinese Multi-provincial Cohort Study2025 · 4 citations
  5. 52247-P: Uncertainty-Calibrated Prediction of Cardiovascular–Kidney–Liver–Metabolic Disease Using Clinical Biomarkers and Plasma Proteomics2026