September 18, 2025Frontiers in ImmunologyOpen Access

Evaluation of microsatellite instability patterns in mismatch repair deficiency: a retrospective analysis of 285 endometrial cancers

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Retrospective analysis evaluated microsatellite shifts in 285 endometrial cancers, indicating MMR's role in cancer diagnosis.

MMR-deficient endometrial cancers show a high frequency of minimal microsatellite shifts, particularly with isolated loss of MSH6.
Of 285 MMR-deficient cases, 169 (59.3%) had combined loss of MLH1 and PMS2, showing notable shifts in microsatellite patterns.
The combination of MMR-IHC and MSI-PCR assays was found to decrease inconsistency rates in MSI detection to 7.7% using minimal shifting criteria.
Results highlight the potential for enhanced accuracy in MSI detection, which could improve treatment strategies for endometrial cancers and personalize patient care.

Wang et al. (2025) studied this question.

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