Microsatellite Instability and Myometrial Infiltration in Low-Grade Endometrial Cancer: A Focus on MMR Heterodimer Dysfunction by a Retrospective Multicentric Italian Study
Retrospective study links microsatellite instability and myometrial infiltration in endometrial cancer, suggesting implications for treatment planning.
Key Points
Myometrial infiltration is observed in 96% of MSS and 98% of MSI cases, indicating a high prevalence of infiltration.
Deep infiltration (≥50%) was significantly more common in patients with MSI at 38%, compared to 19% for MSS cases.
Analysis utilized immunohistochemical profiling of MMR proteins, using logistic regression to evaluate the impact of microsatellite status.
MSI profiling may aid in stratifying risk for deep infiltration in endometrial cancer, especially for fertility-sparing approaches.