Mismatch Repair Deficiency in Gliomas: A Rare Insight into Microsatellite Instability and Its Diagnostic Implications

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Discussion

Observational analysis shows rare mismatch repair deficiency in gliomas, indicating its potential diagnostic implications.

MMR deficiency was observed in 3 of 64 glioma cases, indicating a rare occurrence.
Immunohistochemistry revealed isolated MSH6 loss in all deficient cases, suggesting a specific pattern.
Statistical analyses showed no significant associations between MMRD and patient age or histological subtype.
Next-generation sequencing identified one MSI-high and one MSI-low tumor, highlighting the importance of molecular diagnostics.

Rajendiran et al. (2025) studied this question.

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