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September 18, 2025Journal of Nutrition and MetabolismOpen Access

Novel Causal Evidence for the Role of Circulating Lipid Metabolites in Breast Cancer Risk: A Bidirectional Mendelian Randomization Analysis

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Authors

CZCheng ZengSLShuning LiuYWYuhan Wei

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Overview

Bidirectional Mendelian randomization reveals lipid metabolites impact estrogen receptor-positive breast cancer risk, suggesting diagnostic potential.

Key Points

  • Three lipid metabolites were significantly linked to an increased risk of ER+ breast cancer.
  • Among 386 lipid metabolites studied, 24 showed associations with ER+, while none remained significant for ER− after correction.
  • Using a Mendelian randomization approach allowed robust testing for causal relationships between lipid metabolites and breast cancer.
  • Findings suggest specific lipid metabolites could be used as biomarkers for early detection and preventive interventions.

Cite This Study

Zeng et al. (2025) studied this question.

synapsesocial.com/papers/68d434e3713b0b5dfea744behttps://doi.org/10.1155/jnme/2292774
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