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August 15, 2025MedicineOpen Access

Causal relationship between plasma lipidome and 6 types of cancer: A Mendelian randomization study

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Authors

NTNing TangJTJames TangJZJingting Zhang

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Overview

Mendelian randomization shows lipid species impact cancer risk in various populations, suggesting metabolic links.

Key Points

  • The study identified distinct lipid species with causal links to six types of cancer, illuminating metabolic pathways involved.
  • Phosphatidylethanolamine increases hepatic cancer risk, while sphingomyelin demonstrates protective effects in multiple cancers.
  • Mendelian randomization and inverse variance weighted analysis were utilized, revealing significant associations between lipids and cancer.
  • Findings highlight the potential for lipid interventions in cancer prevention and treatment, underscoring metabolic and pathophysiological insights.

Cite This Study

Tang et al. (2025) studied this question.

synapsesocial.com/papers/68af2d83cf1dd9ea359e5c74https://doi.org/10.1097/md.0000000000043900
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  5. 5Lipidomic Profiling in Cancer: Phospholipid Alterations and their Role in Tumor Progression2025