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September 10, 2025British Journal of CancerOpen Access

Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk

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Authors

TYThomas YatesMWMolly WentCMC. Mills

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Overview

Mendelian randomisation demonstrates obesity's impact on metabolites in cancer risk, suggesting interventional targets.

Key Points

  • Mendelian randomisation analysis reveals multiple metabolites influencing cancer risk related to obesity.
  • Analysis identified 107 BMI-driven and 126 WHR-driven metabolites, with specific links to colorectal cancer.
  • Approach utilized two-sample Mendelian randomisation to examine metabolites from 384,738 cancer cases and 799,908 controls.
  • Findings suggest obesity-related metabolic alterations may serve as targets for cancer interventions.

Cite This Study

Yates et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64781982https://doi.org/10.1038/s41416-025-03170-7
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