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September 18, 2025Acta Alimentaria

Ultrasound-assisted optimisation of Cinnamomum cassia (L.) polyphenol extraction and their antidiabetic effects via AMPK – GLUT4 activation

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Authors

FPF. PengJZJ.W. ZhangZWZhiwei Wang

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Overview

This research demonstrates antidiabetic effects of Cinnamomum cassia polyphenols via AMPK and GLUT4 activation, suggesting potential benefits for diabetes management.

Key Points

  • Cinnamomum cassia polyphenols significantly increased glucose consumption in insulin-resistant cells, suggesting therapeutic benefits.
  • Ultrasound-assisted extraction optimized extraction efficiency to 4.093%, enhancing yield of bioactive compounds.
  • Inhibition of gluconeogenic enzymes PEPCK and G6Pase was observed alongside increases in superoxide dismutase and catalase levels.
  • Activating the AMPK-GLUT4 axis highlights potential molecular mechanisms behind the antidiabetic effects of polyphenols.

Cite This Study

Peng et al. (2025) studied this question.

synapsesocial.com/papers/68d433b8713b0b5dfea738ffhttps://doi.org/10.1556/066.2025.00098
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