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July 14, 2025Current Issues in Molecular BiologyOpen Access

The Antidiabetic Mechanisms of Cinnamon Extract: Insights from Network Pharmacology, Gut Microbiota, and Metabolites

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Authors

RWRong WangKYKuan YangXLXuefeng Liu

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Overview

Network pharmacology identifies 471 targets in type 2 diabetes, suggesting cinnamon impacts gut microbiota.

Key Points

  • Cinnamon extract shows potential in treating type 2 diabetes by improving glucose and lipid metabolism.
  • In vivo studies indicated cinnamon alleviates hyperglycemia and insulin resistance and alters gut microbiota composition.
  • Chemical profiling identified 32 active ingredients, including quercetin, and highlighted key metabolic pathways involved.
  • Cinnamon enhances gut barrier function and reduces proinflammatory cytokines, indicating its therapeutic relevance.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689a02b6e6551bb0af8cc2cbhttps://doi.org/10.3390/cimb47070543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antidiabetic effects of cinnamon (Cinnamomum sp.) and the influence of the compounds it contains2025
  2. 2Efficacy of Cinnamon in Treating Individuals with Diabetes: An Updated Systematic Review and Meta-analysis2025
  3. 3Effects of Cinnamon Bark Extract, Moderate Intensity Exercise, Intermittent Fasting, Metformin on Fasting Blood Glucose Levels, Lipid Profile and Malondialdehyde in DMT2 Rats: Case Study2025
  4. 4Network Pharmacology insights into the Anti-Diabetic Mechanisms of Syzygium cumini Seeds in type 2 Diabetes Mellitus2025
  5. 5Ultrasound-assisted optimisation of Cinnamomum cassia (L.) polyphenol extraction and their antidiabetic effects via AMPK – GLUT4 activation2025