September 18, 2025International Journal of Molecular SciencesOpen Access

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

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Microglial dysfunction leads to impaired amyloid-beta clearance and ongoing inflammation in Alzheimer's disease and HIV-associated neurocognitive disorders.
Critical microglial receptors like TREM2 and Toll-like receptors coordinate amyloid-beta sensing and inflammatory responses, impacting neuronal health.
Both HIV infection and its proteins disrupt microglial function, promoting a cycle of neurotoxicity that exacerbates amyloid accumulation.
Research gaps persist in understanding the full effects of HIV on microglial function, highlighting the need for further studies in this area.

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Implication

This review demonstrates how microglial dysfunction affects amyloid-beta clearance in Alzheimer's and HIV-associated neurocognitive disorders, indicating severe neuroinflammation.

Cite This Study

Njoku et al. (2025) studied this question.

synapsesocial.com/papers/68d433a3713b0b5dfea72eb3 https://doi.org/10.3390/ijms26189069

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Implication

This review demonstrates how microglial dysfunction affects amyloid-beta clearance in Alzheimer's and HIV-associated neurocognitive disorders, indicating severe neuroinflammation.

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

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Discussion

Implication

Cite This Study

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

Key Points

Discussion

Implication

Cite This Study

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