Oxidative Stress in HIV-Associated Neurodegeneration: Mechanisms of Pathogenesis and Therapeutic Targets

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This review uncovers the role of oxidative stress in neurocognitive disorders among HIV patients, highlighting potential therapeutic targets.

HIV-associated neurocognitive disorders (HAND) are prevalent in aging individuals with HIV, despite effective treatment.
Oxidative stress from reactive oxygen species (ROS) plays a key role in the pathogenesis of HAND.
Current therapies targeting HAND include antioxidant strategies and PARP inhibitors to reduce neuroinflammation.
Understanding these mechanisms may lead to better therapeutic interventions for HIV-related neurodegeneration.

Gagliardi et al. (2025) studied this question.

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This review uncovers the role of oxidative stress in neurocognitive disorders among HIV patients, highlighting potential therapeutic targets.