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August 21, 2025NutrientsOpen Access

Type 2 Diabetes and the Multifaceted Gut-X Axes

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Authors

HGHuijuan GuoLPL.-T. PanQWQiuyi Wu

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Overview

Comprehensive review explores gut's role in metabolism and insulin resistance in type 2 diabetes, suggesting therapeutic targets.

Key Points

  • Disruptions in gut homeostasis drive inflammation and insulin resistance, contributing to type 2 diabetes.
  • Key molecular mechanisms like incretins and bile acids influence metabolic pathways across multiple organs.
  • Integrated model highlights crosstalk between gut and pancreas, liver, kidney, and endocrine system in type 2 diabetes.
  • Modulating gut microbiota may improve glycemic control and reduce complications in type 2 diabetes.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68af75207567bf4f94feea4bhttps://doi.org/10.3390/nu17162708
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