September 16, 2025Open Access

Molecular rewiring of human induced pluripotent stem cell-derived cardiomyocytes during metabolic maturation

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Investigation reveals hormonal and metabolic factors influencing gene regulation in hiPSC-CMs, suggesting new insights into cardiotoxicity.

MIF treatment induces extensive rewiring of gene expression and proteomics profiles in hiPSC-CMs, leading to metabolic maturation.
By monitoring mTORC1 activity, the study found that maturation stimuli suppress its signaling during the maturation timeline.
The multiomics approach highlights the molecular mechanisms that drive cardiomyocyte maturation from hiPSCs into a mature state.
Altered chromatin organization in MIF-treated hiPSC-CMs affects extracellular matrix and contractile gene expression, linking to potential cardiotoxicity.

Hamledari et al. (2025) studied this question.

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Investigation reveals hormonal and metabolic factors influencing gene regulation in hiPSC-CMs, suggesting new insights into cardiotoxicity.