September 10, 2025PharmaceuticalsOpen Access

Metabolic Maturation in hiPSC-Derived Cardiomyocytes: Emerging Strategies for Inducing the Adult Cardiac Phenotype

View Full Paper

Ask AI

Bookmark

Authors

DMDaniela MalanUniversity of Bonn MGMaria Pia GalloAccademia Albertina delle Belle Arti FGFederica GeddoAccademia Albertina delle Belle Arti

Discussion

Member takes

Implication

This review outlines strategies to enhance metabolic maturation and achieve an adult cardiac phenotype in hiPSC-derived cardiomyocytes, indicating potential applications in cardiac studies.

Key Points

Metabolic maturation is crucial for hiPSC-derived cardiomyocytes to display adult-like properties, which improves their utility in research.
The review emphasizes various strategies, including culture medium composition and 3D culture methods, to promote adult cardiac characteristics in hiPSC-CMs.
A standardized protocol for hiPSC-CM maturation could facilitate patient-specific cardiac studies and drug testing.
Utilizing hiPSC-derived cardiomyocytes represents an innovative approach to explore cardiac diseases, bridging basic research and clinical applications.

Cite This Study

Malan et al. (2025) studied this question.

synapsesocial.com/papers/68c2404eb210217d6479a797 https://doi.org/10.3390/ph18081133

View Full Paper

Ask AI

Bookmark

Implication

This review outlines strategies to enhance metabolic maturation and achieve an adult cardiac phenotype in hiPSC-derived cardiomyocytes, indicating potential applications in cardiac studies.

Metabolic Maturation in hiPSC-Derived Cardiomyocytes: Emerging Strategies for Inducing the Adult Cardiac Phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic Maturation in hiPSC-Derived Cardiomyocytes: Emerging Strategies for Inducing the Adult Cardiac Phenotype

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider