September 10, 2025BioChemOpen Access

Enhancing Mitochondrial Maturation in iPSC-DerivedCardiomyocytes: Strategies for Metabolic Optimization

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DSDhienda C. ShahannazCleveland Clinic TSTadahisa SugiuraAlbert Einstein College of Medicine BFBrandon E. FerrellAlbert Einstein College of Medicine

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Implication

Systematic review evaluates metabolic preconditioning and biomechanical conditioning to improve mitochondrial function in iPSC-derived cardiomyocytes.

Key Points

Metabolic preconditioning enhanced mitochondrial architecture and ATP production in iPSC-derived cardiomyocytes.
Substrate manipulation led to a shift toward adult-like metabolism, improving cellular resilience and function.
Computational models predicted optimal metabolic interventions aligning iPSC-CM metabolism with native cardiomyocytes.
Integration of metabolic optimization and mechanical stimulation may accelerate iPSC-derived cardiomyocyte maturation.

Cite This Study

Shahannaz et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d64794d6d https://doi.org/10.3390/biochem5030023

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Implication

Systematic review evaluates metabolic preconditioning and biomechanical conditioning to improve mitochondrial function in iPSC-derived cardiomyocytes.

Enhancing Mitochondrial Maturation in iPSC-DerivedCardiomyocytes: Strategies for Metabolic Optimization

Discussion

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Key Points

Cite This Study

Enhancing Mitochondrial Maturation in iPSC-DerivedCardiomyocytes: Strategies for Metabolic Optimization

Discussion

Member takes

Implication

Key Points

Cite This Study

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