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September 16, 2025BMJ Open Respiratory ResearchOpen Access

High BMI and smoking jointly cause COPD: a Mendelian randomisation study

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Authors

HMHeidi MikkelsenELEskild LandtSMSarah C. W. Marott

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Overview

Mendelian randomisation reveals that high BMI and smoking together increase COPD risk more than each alone.

Key Points

  • High BMI and smoking increase the risk for COPD, but their combination significantly elevates this risk.
  • The study analyzed data from 112,943 adults, finding a notable link between allele scores and COPD risk.
  • Using Mendelian randomisation, both risk factors were shown to affect COPD independently and in combination.
  • The findings suggest that addressing both high BMI and smoking is crucial in COPD prevention strategies.

Cite This Study

Mikkelsen et al. (2025) studied this question.

synapsesocial.com/papers/68d42321713b0b5dfea6acb3https://doi.org/10.1136/bmjresp-2024-002825
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