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December 4, 2025MedicineOpen Access

Mendelian randomization analysis of the causal relationship between COPD and type 1 and type 2 diabetes mellitus

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Authors

YPYueshan PangLZLisha Zhu

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Overview

Analysis observes a marginal causal link between COPD and type 1 diabetes in Europeans, suggesting further investigation is needed.

Key Points

  • COPD is marginally associated with type 1 diabetes, with an odds ratio of 1.91 in European populations.
  • Confidence interval for the association ranged from 1.0003 to 3.0016, indicating some uncertainty in findings.
  • Sensitivity analyses confirmed no issues with directional pleiotropy or heterogeneity, strengthening the results' reliability.
  • Further research with larger cohorts is necessary to substantiate the weak association and explore mechanisms.

Cite This Study

Pang et al. (2025) studied this question.

synapsesocial.com/papers/6930dc9eea1aef094cca2dbchttps://doi.org/10.1097/md.0000000000045935
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