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September 10, 2025Journal of Thoracic DiseaseOpen Access

Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study

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Authors

WFWeiyi FengJZJun‐Huang ZhengJXJiaqi Xiao

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Overview

Mendelian randomization analysis shows positive association between remnant cholesterol and COPD, suggesting potential implications for lipid management.

Key Points

  • Remnant cholesterol levels were positively associated with the risk of chronic obstructive pulmonary disease.
  • The odds ratio from Mendelian randomization analysis indicated a significant link between high remnant cholesterol and increased COPD risk (OR: 1.222).
  • Analysis utilized pooled data from the Integrative Epidemiology Unit and FinnGen Biobank, focusing on European ancestry.
  • These findings may highlight a novel association that calls for further research on lipid levels in relation to COPD.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68c23e02b210217d64790639https://doi.org/10.21037/jtd-24-1894
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk2025 · 3 citations
  2. 2Multi-Ancestry Mendelian Randomization Reveals Lipid-Associated Genetic Risk Factors for COPD2025 · 1 citations
  3. 3Remnant cholesterol inflammatory index and chronic lung disease in middle-aged and older Chinese adults: A cross-sectional analysis of the China Health and Retirement Longitudinal Study2026
  4. 4Variations in remnant cholesterol and the risk of cardiovascular disease: a national longitudinal cohort study2025
  5. 5The causal effects of remnant cholesterol on increased risk of cardiovascular diseases in East Asians2025