MMR-Colon Study: First Attempt at Quantifying MMR Protein Expression as a Prognostic Factor in Colorectal Cancer

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Discussion

Analysis quantifies MMR protein levels and their impact on survival in colorectal cancer patients, suggesting a prognostic link.

High-grade tumor budding is linked to lower MSH6 expression, with an odds ratio of 11.20.
Low MMR expression correlates with more aggressive histotypes and perineural invasion but not survival impact.
The study included 73 patients, median age 74, predominantly presenting with CRC of histologic grade G2.
Further investigations on larger cohorts are essential to verify the findings due to significant variability.

Bertolina et al. (2025) studied this question.

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