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September 23, 2025The FASEB JournalOpen Access

Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease

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Authors

JTJordyn ThomasPBPanashe BamhareJMJocelyne Mulangala

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Overview

Investigating how apolipoprotein c3 impacts angiogenesis in peripheral artery disease models suggests new therapeutic targets.

Key Points

  • ApoC3 promotes pathological angiogenesis, leading to increased neovessel formation in inflammatory models of peripheral artery disease.
  • Neovessel formation was reduced by approximately 40% in Apoc3-deficient mice compared to Apoc3 +/+ counterparts.
  • Using an inflammatory periarterial cuff model and other experimentation revealed how ApoC3 stimulates endothelial cell activity and inflammation.
  • The findings suggest potential therapeutic targeting of ApoC3 for pathological angiogenesis without compromising necessary ischemic responses.

Cite This Study

Thomas et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7ea40https://doi.org/10.1096/fj.202502155r
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