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December 8, 2025BloodOpen Access

A murine monoclonal antibody to integrin αIIbβ3 that inhibits protein disulfide isomerase binding to platelets and platelet aggregation

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Authors

LWLu WangJWJialing WangJLJihong Li

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Overview

Experimental analysis shows R21C11 reduces fibrinogen binding in platelets, indicating its potential role in thrombosis and hemostasis.

Key Points

  • R21C11 inhibits platelet aggregation by reducing fibrinogen binding and PDI interactions.
  • Binding analysis revealed a 70% reduction in PDI binding to activated platelets at 40 µg/ml R21C11.
  • Cryogenic electron microscopy confirmed R21C11 binds to the β-tail domain of integrin αIIbβ3.
  • These findings highlight R21C11's potential therapeutic significance in managing thrombosis.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df11https://doi.org/10.1182/blood-2025-3016
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