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September 12, 2025

Gut Clostridia and Gammaproteobacteria metabolize dietary linoleic acid to produce a signature of microbial polyunsaturated fatty acids and associated lipids

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Authors

ZHZongyao HuyanNPNicoletta PellegriniZLZhen Liu

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Overview

This study uncovers how gut microbes metabolize linoleic acid and produce microbial lipids, indicating significant roles of Clostridia and Gammaproteobacteria.

Key Points

  • Linoleic acid metabolism in the gut produces diverse microbial lipids, highlighting significant metabolic pathways.
  • Using isotopically labeled linoleic acid, researchers tracked lipid production associated with gut microbial responses.
  • The dynamic gut-simulating environment (SHIME) confirmed the long-term bioprocessing of linoleic acid by gut microbiota.
  • Influence of dietary protein-to-fiber ratio on PUFA concentration underscores the connection between diet and gut microbial activity.

Cite This Study

Huyan et al. (2025) studied this question.

synapsesocial.com/papers/68d41dae713b0b5dfea6734chttps://doi.org/10.1101/2025.09.11.675017
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Also Consider

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  1. 1A Comprehensive Review on Medium- and Long-Chain Fatty Acid-Derived Metabolites: From Energy Sources to Metabolic Signals2026
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  4. 4Probiotic Potentials and Protective Effects of Ligilactobacillus animalis LA-1 Against High-Fat Diet-Induced Obesity in Mice2025 · 1 citations
  5. 5Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies2025