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September 10, 2025NutrientsOpen Access

Probiotic Potentials and Protective Effects of Ligilactobacillus animalis LA-1 Against High-Fat Diet-Induced Obesity in Mice

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Authors

QWQinyu WangYHYuyin HuangKMKun Meng

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Overview

Ligilactobacillus animalis LA-1 reduces weight gain and improves gut microbiota in mice, highlighting its potential as an anti-obesity probiotic.

Key Points

  • Ligilactobacillus animalis LA-1 significantly reduced weight gain in mice on a high-fat diet while maintaining food intake.
  • Supplementation with LA-1 led to improved serum lipid profiles and decreased liver injury markers over 16 weeks.
  • Multi-omics analyses revealed increased short-chain fatty acid levels and modulation of metabolic pathways associated with obesity.
  • This study supports the potential of LA-1 as a targeted probiotic intervention for obesity and metabolic disorders.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f424https://doi.org/10.3390/nu17142346
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