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August 19, 2025Microbiome Research ReportsOpen Access

Recent advances in gut microbiota-mediated regulation of fat deposition and metabolic disorders

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Authors

XCXiaoyan CuiQYQuan YuanJLJiali Long

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Overview

Observational analysis shows dysbiosis links gut microbiota to obesity and metabolic disorders, suggesting new therapeutic approaches.

Key Points

  • Dysbiosis exacerbates insulin resistance and adipose inflammation, impacting metabolic health.
  • Short-chain fatty acids derived from dietary fiber enhance mitochondrial β-oxidation and inhibit lipogenesis.
  • Microbial metabolites like bile acids and branched-chain amino acids influence fat deposition and metabolic disorders.
  • Future strategies should focus on precision engineering of gut microbiota to improve metabolic outcomes in humans and livestock.

Cite This Study

Cui et al. (2025) studied this question.

synapsesocial.com/papers/68af35e3cf1dd9ea359ea166https://doi.org/10.20517/mrr.2025.25
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  3. 3Interaction mechanism and intervention strategy between metabolic dysfunction-associated steatotic liver disease and intestinal microbiota2025
  4. 4Physiological Mechanisms of and Therapeutic Approaches to the Gut Microbiome and Low-Grade Inflammation in Obesity2025
  5. 5Beyond Digestion: The Gut Microbiota as an Immune-Metabolic Interface in Disease Modulation<b></b>2025 · 9 citations