September 12, 2025

Differential Roles of Notch Receptors in Regulating Activation of Intact Adult Mouse Spinal Cord-derived NSCs

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Notch receptors critically regulate activation of adult spinal cord-derived neural stem cells.
Notch1 expression levels were significantly higher, suggesting its primary role in NSC activation.
Both Notch2 and Notch3 are key for maintaining NSCs in a quiescent state.
Single-cell RNA sequencing was used to analyze NSC properties and Notch signaling pathways.

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Implication

This study demonstrates the differential roles of Notch receptors in regulating NSC activation in C57/BL6 mice, highlighting Notch1's primordial role.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d418e1713b0b5dfea64dfa https://doi.org/10.21203/rs.3.rs-7540357/v1

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Implication

This study demonstrates the differential roles of Notch receptors in regulating NSC activation in C57/BL6 mice, highlighting Notch1's primordial role.

Differential Roles of Notch Receptors in Regulating Activation of Intact Adult Mouse Spinal Cord-derived NSCs

Key Points

Discussion

Implication

Cite This Study

Differential Roles of Notch Receptors in Regulating Activation of Intact Adult Mouse Spinal Cord-derived NSCs

Key Points

Discussion

Implication

Cite This Study

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Also Consider