Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential
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Key Points
Notch signaling blockade causes distinct behaviors in quiescent neural stem cells, affecting their activation and differentiation.
Single-cell RNA sequencing identified molecular clusters of quiescent neural stem cells with varying quiescence depths, highlighting their heterogeneity.
The transcription factor Nr2f1b mediates the resistance to activation of certain deeply quiescent neural stem cells challenged by Notch signaling blockade.
Findings indicate that the molecular heterogeneity of quiescent neural stem cells is linked to their biological properties and regulators.
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