August 4, 2025Open Access

Jagged-mediated lateral induction patterns Notch3 signaling within adult neural stem cell populations

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Notch3 signaling controls neural stem cell quiescence and stemness in adult zebrafish.
High Notch3 signaling levels surround cells with low N3ICD expression, which express deltaA ligand.
Jagged1b interacts positively with Notch3, maintaining Sox2 expression in neural stem cells.
Lowering jagged1b disrupts the distribution of Notch3 signaling levels without altering overall patterns.

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Study shows Notch3 signaling affects quiescence and stemness in neural stem cells, indicating jagged1b plays a crucial role.

Ortica et al. (2025) studied this question.

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