September 19, 2025Open Access

Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexia

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Tumor growth enhances specific mTORC1 signaling pathways in skeletal muscle, leading to muscle wasting in cachexia.
Single-nucleus RNA sequencing revealed that pancreatic cancer induces significant alterations in muscle gene expression.
Inhibition of mTORC1 exacerbates muscle loss in tumor-bearing KPC mice, implying its protective role in cachexia.
Novel intercellular signaling networks were found in skeletal muscle, indicating complex regulation mechanisms during cachexia.

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Observational analysis reveals mTORC1 signaling alterations in skeletal muscle during cachexia, suggesting therapeutic targets.

Xu et al. (2025) studied this question.

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