August 22, 2025Open Access

Elucidating cancer cachexia-mediated aberrant cardiac wasting signaling in human iPSC-derived cardiac muscle

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Cachexia-induced cardiac wasting leads to significant impairments in muscle function and metabolism, with long-term repercussions.
Cardiac myocytes showed reduced contraction amplitude and prolonged relaxation time, indicating severe functional impairment in cachexia.
Mechanistic studies focused on the Atrogin-1/Calcineurin A/NFAT signaling pathway, revealing its central role in cardiac atrophy.
The findings highlight the necessity for further exploration of targeted interventions to mitigate cancer cachexia-induced cardiac dysfunction.

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Experimental analysis uncovered the Atrogin-1/Calcineurin A/NFAT axis driving cardiac wasting in cachexia, suggesting new treatment targets.

Hosny et al. (2025) studied this question.

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Experimental analysis uncovered the Atrogin-1/Calcineurin A/NFAT axis driving cardiac wasting in cachexia, suggesting new treatment targets.