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September 11, 2025AgingOpen Access

Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos

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Authors

MFMyriam FornageWTWassim TarrafRXRui Xia

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Overview

Longitudinal study shows significant ties between epigenetic aging and cognitive decline in Hispanic/Latino adults, indicating higher dementia risk.

Key Points

  • Greater acceleration of all epigenetic clocks is linked to lower cognitive function at each visit, and higher risk of MCI at V2.
  • Among 2671 Hispanic/Latino adults, the strongest ties were found for GrimAge and DunedinPACE with cognitive decline.
  • Longitudinal assessment indicated PhenoAge and GrimAge acceleration predict cognitive decline and MCI risk more effectively than a single evaluation.
  • The study emphasizes the need for more longitudinal DNAm data in this demographic to better understand these associations.

Cite This Study

Fornage et al. (2025) studied this question.

synapsesocial.com/papers/68d418cd713b0b5dfea63feahttps://doi.org/10.18632/aging.206317
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults2025 · 1 citations
  2. 2Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos2025 · 2 citations
  3. 3Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study2025
  4. 4Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume2026
  5. 5Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer’s disease2025