August 14, 2025Open Access

Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer’s disease

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Analysis reveals biological aging impacts plasma biomarkers in cognitively unimpaired women, suggesting implications for ADRD risk.

Higher AgeAccelPheno correlates with lower Aβ42:Aβ40 ratio, indicating potential early Alzheimer's disease markers.
Longitudinal analysis showed elevated neurofilament light and p-tau levels linked to biological aging over 15 years.
A cohort of 2,366 older women from the Women’s Health Initiative Memory Study was examined for epigenetic aging effects.
Findings suggest accelerated biological aging may serve as a critical factor in monitoring Alzheimer's disease risk.

Zhang et al. (2025) studied this question.

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