Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Clinical EpigeneticsOpen Access

Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults

View Full Paper
Ask AI
Bookmark
Share

Authors

MFMyriam FornageWTWassim TarrafMDMartha L. Daviglus

Discussion

Loading...

Member takes

Overview

This study demonstrates associations of epigenetic aging with amyloid and tau levels in Hispanic/Latino adults, highlighting potential diagnostic indicators.

Key Points

  • Epigenetic age acceleration is linked to higher plasma levels of amyloid beta and tau in Hispanic/Latino adults, indicating a potential connection to Alzheimer's disease.
  • Significant correlations exist between multiple epigenetic clocks and plasma biomarkers, with varying effects noted by sex, especially for the PC-PhenoAge clock.
  • The analysis involved 2656 Hispanic/Latino adults, controlling for factors like age and health conditions, providing comprehensive insights into neurodegeneration biomarkers.
  • Findings emphasize the importance of sex differences in understanding the relationship between biological aging and Alzheimer's biomarkers in diverse populations.

Cite This Study

Fornage et al. (2025) studied this question.

synapsesocial.com/papers/68c23dc5b210217d6478f4c3https://doi.org/10.1186/s13148-025-01941-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DunedinPACE, a DNA methylation biomarker of the pace of aging2022 · 652 citations
  2. 2SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions2018 · 617 citations