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September 11, 2025

Age-Stratified Immune Characteristics in Central Nervous System Tuberculosis Patients: A Comparative T lymphocyte Subset Analysis within a Cohort of 862 Extrapulmonary Tuberculosis Patients

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Authors

MCMuxing ChenFZFan ZhangYLYiping Liu

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Overview

Retrospective analysis reveals T lymphocyte depletion and elevated NLR in CNS-TB patients, indicating age-dependent immune responses.

Key Points

  • CNS-TB patients exhibit notable T lymphocyte depletion, especially in adults aged 25–54 years, highlighting critical immune deficiencies.
  • In CNS-TB, significant reductions in CD3+, CD4+, and CD8+ T lymphocyte counts were found compared to non-CNS patients, with p-values <0.001 for most subsets.
  • This analysis utilized a retrospective study design comprising 862 patients with extrapulmonary tuberculosis admitted over six years, enabling detailed comparison across age groups.
  • Findings indicate the importance of age stratification for understanding immune responses in CNS-TB, supporting targeted monitoring and therapeutic strategies.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d41717713b0b5dfea62d72https://doi.org/10.21203/rs.3.rs-7519458/v2
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Also Consider

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  1. 1Age-Stratified Immune Characteristics in Central Nervous System Tuberculosis Patients: A Comparative T lymphocyte Subset Analysis within a Cohort of 862 Extrapulmonary Tuberculosis Patients2025
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