September 10, 2025PhytomedicineOpen Access

Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites

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Gastrodin significantly alleviated symptoms of ulcerative colitis in a mouse model, enhancing gut health.
Key findings indicated that gastrodin enriched Akkermansia muciniphila, which may act against inflammation.
The study utilized 16S rRNA sequencing to analyze gut microbiota changes and metabolomics to track metabolic shifts.
These results support the idea that herbal treatments like gastrodin may offer new strategies for managing ulcerative colitis.

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Implication

Observational analysis revealed that gastrodin improved colitis symptoms in mice by enriching Akkermansia muciniphila, suggesting a microbiota-focused approach.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479f8f5 https://doi.org/10.1016/j.phymed.2025.157138

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Implication

Observational analysis revealed that gastrodin improved colitis symptoms in mice by enriching Akkermansia muciniphila, suggesting a microbiota-focused approach.

Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites

Key Points

Discussion

Implication

Cite This Study

Gastrodin ameliorates DSS-induced ulcerative colitis via enhancing the abundance of Akkermansia muciniphila and modulating the metabolites

Key Points

Discussion

Implication

Cite This Study

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