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September 10, 2025JMIR Public Health and SurveillanceOpen Access

Validation and Refinement of Scores to Predict Stroke Risk: Prospective Cohort Study

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Authors

HMHua MengZLZhuo LiuDPDongfeng Pan

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Overview

Prospective cohort study validated the ‘8+2’ stroke risk score, revealing limitations and refining predictive models.

Key Points

  • The ‘8+2’ stroke risk score inadequately predicts stroke events, indicating a need for improved models.
  • The Rothman-Keller model demonstrated a better predictive ability for stroke with significant net reclassification improvement.
  • Using a sample of 100,000 participants, the study established valid threshold points for assessing stroke risk.
  • Further research incorporating biomarkers is necessary to enhance stroke risk prediction accuracy.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a8707https://doi.org/10.2196/72497
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development and Internal Validation of a Clinical Imaging–Based Stroke Prediction Model in a Community Cohort2025
  2. 2Abstract 520: STRIKE: A Machine Learning Model for 10‐Year Stroke Risk Estimation2025
  3. 3Association Between Life’s Essential 8 Score and Stroke Risk in American Adults2025
  4. 4Performance of Stratification Scores on the Risk of Stroke After a Transient Ischemic Attack: A Systematic Review and Network Meta-Analysis2025
  5. 5Using SCORE2 with a risk chart or online calculator: Impact on model performance, treatment eligibility and cardiovascular disease prevention2025 · 5 citations