LC–ESI–MS/MS Profiling and In Vitro Evaluation of Antioxidant, Enzymatic Inhibitory, and Cytotoxic Activities, Along With Complementary In Vitro and In Silico Assessment of the Antibacterial Potential of Centaurea papposa Leaf Extracts

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In vitro assessment reveals potential antioxidant and antibacterial effects of centaurea papposa extracts, suggesting therapeutic applications.

The ethyl acetate fraction of centaurea papposa showed significant cytotoxic activity against cancer cells with an IC50 below 40 µg/mL.
Molecular docking analysis indicated that salicylic acid has strong interactions in the target enzyme's active site with a docking score of −6.901 kcal/mol.
The chloroform fraction demonstrated antibacterial activity against multiple bacteria, including Staphylococcus aureus and Escherichia coli with an MIC of 62.5 µg/mL.
The study identified key phenolic compounds like shikimic acid and chlorogenic acid through LC‐MS/MS analysis from centaurea papposa leaf extracts.

Bounaas et al. (2025) studied this question.

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In vitro assessment reveals potential antioxidant and antibacterial effects of centaurea papposa extracts, suggesting therapeutic applications.