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September 5, 2025Cancer Cell InternationalOpen Access

Integration of multi-omics approaches in exploring intra-tumoral heterogeneity

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Authors

MDMengmeng DongLWLiping WangNHNa Hu

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Overview

This review outlines the clinical applications of multi-omics to tackle intra-tumoral heterogeneity, highlighting challenges and implications.

Key Points

  • Integration of multi-omics enhances understanding of intra-tumoral heterogeneity, informing diagnosis and treatment plans.
  • Recent advancements in technologies like genomics and transcriptomics have allowed a comprehensive analysis of tumors.
  • Challenges in clinical translation include technical hurdles and conceptual gaps in applying multi-omics approaches.
  • Emphasis is on biomarker discovery and patient stratification to overcome treatment resistance linked to heterogeneity.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477aaa4https://doi.org/10.1186/s12935-025-03944-2
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  4. 4Multi-omics perspectives for gastrointestinal malignancy: A systematic review2025
  5. 5Systems biology approaches for multi omics integration using artificial intelligence2026