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September 10, 2025Nature and Science of SleepOpen Access

Sleep Duration and Cardiometabolic-Kidney-Metabolic Syndrome: The Role of Depressive Symptoms in a Longitudinal Study

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Authors

YPYixuan PanJBJingru BiLFLong Feng

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Overview

Longitudinal study shows sleep duration affects cardiometabolic-kidney-metabolic syndrome risk, highlighting depressive symptoms as a mediator.

Key Points

  • Short sleep duration significantly increases the risk of CKM syndrome, with an adjusted odds ratio of 1.148.
  • Persistently abnormal sleep over two years further elevates CKM risk, noted with an odds ratio of 1.259.
  • Causal mediation analysis indicates depressive symptoms partially mediate the association between sleep duration and CKM risk.
  • Subgroup analyses reveal stronger CKM associations among women and less educated individuals, suggesting targeted interventions.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4d49https://doi.org/10.2147/nss.s537555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between cardiovascular-kidney-metabolic syndromeand depressive symptoms in middle-aged and older Chineseadults: a cross-sectional and longitudinal analysis2026
  2. 2Association between changes in sleep duration and the risk of incident depressive symptoms among Chinese middle-aged and older adults2025
  3. 3Joint Association of Depression and Sleep Duration With All‐Cause and Cardiovascular Mortality: A Cross‐Sectional Study With Inflammation Mediation Analysis2025
  4. 4Sleep Duration Modifies the Association of Alternate Mediterranean Diet Score with Metabolic Syndrome in Mid-Life Women in Mexico2025
  5. 5Associations of metabolic heterogeneity of obesity, cardiometabolic index with sleep trajectory among middle-aged and older adults: a longitudinal study2025