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September 10, 2025BioScience TrendsOpen Access

APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications

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Authors

JCJiajie ChenSZShuoyan ZhaoYZYingying Zhou

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Overview

This review highlights lipid metabolism changes in microglia in Alzheimer's disease, revealing APOE4's role and the implications for neuroinflammation.

Key Points

  • Microglial reprogramming by APOE4 impairs lipid metabolism and phagocytosis linked to AD.
  • In Alzheimer’s disease, disrupted lipid metabolism and neuroinflammation worsen cognitive decline.
  • The review provides insights into the pathways activated by APOE4 in microglial dysfunction.
  • Emerging therapeutic strategies focus on targeting lipid metabolic disturbances to mitigate AD effects.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a493chttps://doi.org/10.5582/bst.2025.01148
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microglia-to-neuron signaling links <i>APOE4</i> and inflammation to enhanced neuronal lipid metabolism and network activity2025
  2. 2Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions2025
  3. 3Microglia-to-neuron signaling increases lipid droplet metabolism, enhancing neuronal network activity2025
  4. 4Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer’s disease2025
  5. 5APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics2025