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September 10, 2025Open Access

Prognostic Factors Associated with Biochemical Relapse after Radiotherapy in Localized Prostate Cancer: A Retrospective Cohort Study

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Authors

NFN. FeltesFCFelipe CouñagoHospital Universitario La PazSRSaturio Paredes Rubio

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Implication

Retrospective cohort study reveals Gleason score and PSA levels predict biochemical relapse in localized prostate cancer.

Key Points

  • Higher PSA level at diagnosis and Gleason score are independently linked to biochemical relapse.
  • 11.7% of patients experienced biochemical relapse after a median follow-up of 72 months in the cohort.
  • The study analyzed clinical and histopathological data from 444 localized prostate cancer patients post-treatment.
  • Findings highlight the need for incorporating detailed biopsy metrics into routine clinical risk assessments.

Cite This Study

Feltes et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a186ehttps://doi.org/10.20944/preprints202508.0057.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Factors Associated with Biochemical Relapse After Radiotherapy in Localized Prostate Cancer: A Retrospective Cohort Study2025
  2. 2Time to Prostate‐Specific Antigen Failure as a Unique Prognosticator of Overall Survival in Biochemically Recurrent Prostate Cancer Patients Undergoing Radical Prostatectomy2025 · 1 citations
  3. 3Radiogenomic Profiling of Prostate Tumors prior to External Beam Radiotherapy Converges on a Transcriptomic Signature of TGF-β Activity Driving Tumor Recurrence2025 · 3 citations
  4. 4Incidence, Risk Factors, and Clinical Characteristics of Late Biochemical Recurrence Following Robot‐Assisted Radical Prostatectomy2025
  5. 5Radiation Therapy for Local or Biochemical Recurrence Following Radical Prostatectomy in Patients with Prostate Cancer2025