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September 10, 2025BiomedicinesOpen Access

Prognostic Factors Associated with Biochemical Relapse After Radiotherapy in Localized Prostate Cancer: A Retrospective Cohort Study

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Authors

NFN. FeltesFCFelipe CouñagoSPSaturio Paredes

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Overview

Retrospective cohort study identifies Gleason score and PSA as key predictors of biochemical recurrence in localized prostate cancer.

Key Points

  • Biochemical recurrence occurred in 11.7% of patients after a median follow-up of 72 months.
  • Higher PSA at diagnosis and Gleason scores ≥ 4 were significantly associated with biochemical recurrence.
  • Retrospective analysis of 444 localized prostate cancer patients treated with radiotherapy revealed key predictors.
  • Findings highlight the need for prolonged follow-up as 19.2% of recurrences occurred after five years.

Cite This Study

Feltes et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478cf4chttps://doi.org/10.3390/biomedicines13092185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Factors Associated with Biochemical Relapse after Radiotherapy in Localized Prostate Cancer: A Retrospective Cohort Study2025
  2. 2Time to Prostate‐Specific Antigen Failure as a Unique Prognosticator of Overall Survival in Biochemically Recurrent Prostate Cancer Patients Undergoing Radical Prostatectomy2025
  3. 3Radiogenomic profiling of prostate tumors prior to external beam radiotherapy converges on a transcriptomic signature of TGF-β activity driving tumor recurrence2025
  4. 4Incidence, Risk Factors, and Clinical Characteristics of Late Biochemical Recurrence Following Robot‐Assisted Radical Prostatectomy2025
  5. 5Radiation Therapy for Local or Biochemical Recurrence Following Radical Prostatectomy in Patients with Prostate Cancer2025