September 10, 2025Open Access

Decoding Sepsis: A 16-Year Retrospective Analysis of Activation Patterns, Mortality Predictors, and Outcomes from a Hospital-Wide Sepsis Protocol

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Discussion

Retrospective analysis reveals mortality trends and effectiveness of sepsis protocols in hospitals.

Overall in-hospital mortality declined from 26.5% to 13.6%, indicating improved outcomes over time.
Analysis of 10,919 patients identified hyperlactatemia and altered consciousness as key mortality predictors.
The study utilized a retrospective cohort design, examining hospital-wide sepsis protocol activations over 16 years.
The findings suggest that implementing comprehensive sepsis protocols can enhance patient outcomes significantly.

Borges-Sá et al. (2025) studied this question.

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