September 10, 2025

Decoding Sepsis: A 16-Year Retrospective Analysis of Activation Patterns, Mortality Predictors, and Outcomes from a Hospital-Wide Sepsis Protocol.

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Discussion

Retrospective cohort reveals mortality predictors and outcomes in sepsis management, suggesting improved efficiency.

In-hospital mortality significantly decreased from 26.5% to 13.6% over 16 years, indicating protocol effectiveness.
Retrospective cohort included 10,919 patients with protocol activations linking SIRS criteria to organ dysfunction.
Propensity score analysis identified hyperlactatemia and altered consciousness as key mortality predictors.
Hospital-wide sepsis protocol showed a sustained decrease in ICU admissions, enhancing resource utilization efficiency.

Borges-Sa et al. (2025) studied this question.

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